The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 117, 749-754, Copyright ©, 1963, by The Rockefeller Institute

ARTICLE

THE ROLE OF THE CHEEK POUCH IN EFFECTING TRANSPLANTATION IMMUNITY IN THE HAMSTER

David Shepro Ph.D.1, Nora Kula 1, and James A. E. Halkett 1

1 From Simmons College and Boston University Biological Science Center; Radioisotope Service, Boston Veterans Administration Hospital, Boston

The cheek pouch of the hamster is alymphatic.

Molecules, too large to penetrate the vascular endothelium, reach general circulation by slowly diffusing through the cheek pouch membrane to vessels found in the connective tissues in the neck and these vessels drain primarily into the superficial cervical node.

The tissues of the cheek pouch membrane limit the diffusion of large particles and it is this "barrier" which explains, in part, the "privilege" conferred by the cheek pouch.

 Submitted on January 6, 1963


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