STUDIES ON ARTIFICIAL ANTIGENS: I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS

doi:10.1084/jem.117.1.55

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ARTICLE

STUDIES ON ARTIFICIAL ANTIGENS : I. ANTIGENICITY OF DNP-POLYLYSINE AND DNP COPOLYMER OF LYSINE AND GLUTAMIC ACID IN GUINEA PIGS

Fred S. Kantor M.D.¹, Antonio Ojeda M.D.¹, and Baruj Benacerraf M.D.¹

¹ From the Department of Pathology New York University School of Medicine, New York

Dinitrophenyl conjugates of poly-L-lysine, varying in percentageconjugation and molecular weight have been found to induce skinreactivity and precipitating antibodies in guinea pigs. At best,40 per cent of immunized animals developed delayed and immediateresponses to DNP-polylysine, which is believed to reflect constitutionaldifferences among the animals assayed. Only those animals capableof responding to DNP-polylysine, responded to an immunologicallydistinct poly- $alpha$ -amino acid consisting of glutamyl and lysyl residues("copolymer glu-lys"). The percentage of animals respondingto the DNP-polylysine antigen decreased as the degree of DNPconjugation increased.

Submitted on September 17, 1962

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