The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 116, 273-284, Copyright, 1962, by The Rockefeller Institute

ARTICLE

URINARY CALCULI IN GERMFREE RATS

Bengt E. Gustafsson M.D.1 and Arne Norman M.D.1

1 From the Department of Germfree Research and the Department of Chemistry, Karolinska Institutet, Stockholm, and the Department of Clinical Chemistry, Stockholms Läns Centrallasarett, Danderyd, Sweden

In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared when germfree animals were contaminated with the intestinal flora from conventional rats.

The calculus formation can readily be explained by the high calcium, high citrate, and high pH of the urine. This pattern was changed to that of conventional rats when the germfree rats were infected with intestinal microorganisms.

 Submitted on April 22, 1962


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