EFFECTS OF CHRONIC EXCESS SALT INGESTION: EVIDENCE THAT GENETIC FACTORS PLAY AN IMPORTANT ROLE IN SUSCEPTIBILITY TO EXPERIMENTAL HYPERTENSION

doi:10.1084/jem.115.6.1173

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The Journal of Experimental Medicine, Vol 115, 1173-1190, Copyright, 1962, by The Rockefeller Institute

ARTICLE

EFFECTS OF CHRONIC EXCESS SALT INGESTION : EVIDENCE THAT GENETIC FACTORS PLAY AN IMPORTANT ROLE IN SUSCEPTIBILITY TO EXPERIMENTAL HYPERTENSION

Lewis K. Dahl M.D.¹, Martha Heine ¹, and Lorraine Tassinari ¹

¹ From the Medical Research Center, Brookhaven National Laboratory, Upton, New York

Using the genetic technique of selective inbreeding, it hasbeen possible to quickly develop two statistically separablepopulations from one unselected strain of Sprague-Dawley rats.One of these is very sensitive, the other very resistant, tothe development of experimental hypertension from a high saltdiet. It was suggested that similar genetic factors operatein man.

Submitted on March 4, 1962

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