The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 959-966, Copyright, 1962, by The Rockefeller Institute

ARTICLE

A LIPOGENIC TOXIN RELEASED THROUGH THE INTERACTION OF A NEW CYTOPATHIC AGENT (LIPOVIRUS) AND CULTURED HUMAN CELLS

R. Shihman Chang M.D.1, Robert P. Geyer Ph.D.1, and Stephen B. Andrus M.D.1

1 From the Departments of Microbiology and Nutrition, Harvard School of Public Health, Boston

The release of a toxic product from cultured human cells infected by a new cytopathic agent (the lipovirus) was described. This toxin was dissociable from the infectious particles. It induced sudanophilia of human and mouse cells, an increase in the total fatty acid content, and a change in the major constituent fatty acids. Similar toxin was not demonstrated in cultures infected by the vaccinia herpes simplex, adeno 3, polyoma, polio 1 and 2, Coxsackie B1, parainfluenza A, and Rous sarcoma viruses. Preliminary characterization indicated that this toxin was resistant to tryptic digestion and could not be dialyzed or neutralized by human gamma globulin. It was inactivated at 58°C for 30 minutes, but stable at 37°, 4°, and –60°C. The significance of these findings is discussed.

Submitted on January 1, 1962


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