Frederick G. Germuth Jr. M.D.¹, A. Edward Maumenee M.D.¹, Laurence B. Senterfit Sc.D.¹, and Abou D. Pollack M.D.¹

¹ From the Departments of Pathology and Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, and the Laboratory of Experimental Pathology, Charlotte Memorial Hospital, Charlotte, North Carolina

The injection of antigen into the center of the avascular cornea of homologously sensitized animals induced a ring of opacification between the center of the cornea and the limbus. This ring of opacification was composed of a line of deeply eosinophilic amorphous material in a matrix of swollen collagen fibers, palisaded by polymorphonuclear leucocytes. By use of fluor-tagged antigen, it was shown that the line of damage in the cornea coincided with the precipitation of antigen presumably by antibody entering the cornea from the limbal vessels. With the passage of time, the antigen-antibody precipitates were removed, at least in part by phagocytosis, and the ring of opacification was replaced by ingrowing blood vessels surrounded by plasma cells.

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This article has been cited by other articles:

• LEIBOWITZ, H. M., ELLIOTT, J. H. (1965). Further Studies on the Suppression of Corneal Hypersensitivity by Antimetabolites. Arch Ophthalmol 74: 835-840 [Abstract]  
• LEIBOWITZ, H. M., ELLIOTT, J. H. (1965). Antibody Production in Corneal Hypersensitivity. Arch Ophthalmol 73: 687-695 [Abstract]  
• ELLIOTT, J. H., LEIBOWITZ, H. M. (1965). Corneal Immune Rings Associated With Heterograft Rejection. Arch Ophthalmol 73: 519-527 [Abstract]  
• LEIBOWITZ, H. M., ELLIOTT, J. H. (1965). Antimetabolite Suppression of Corneal Hypersensitivity. Arch Ophthalmol 73: 94-111 [Abstract]  
• DOHLMAN, C. H. (1963). Cornea and Sclera. Arch Ophthalmol 69: 257-278  

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