The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 789-801, Copyright, 1962, by The Rockefeller Institute

ARTICLE

POLYFUNCTIONAL DINITROPHENYL HAPTENS AS REAGENTS FOR ELICITATION OF IMMEDIATE TYPE ALLERGIC SKIN RESPONSES

Charles W. Parker M.D.1, Milton Kern Ph.D.1, and Herman N. Eisen M.D.1

1 From Departments of Internal Medicine, Division of Dermatology, and Microbiology, Washington University School of Medicine, St. Louis

Dinitrophenyl derivatives of differing molecular weights and degrees of substitution have been contrasted with respect to their ability to elicit immediate type allergic responses and their capacity to induce antibody formation in the guinea pig. In contradistinction to dinitrophenyl-proteins, bis-DNP-lysine and DNP-polylysines (including a 100,000 molecular weight derivative) failed to induce antibody detectable by guinea pig passive cutaneous anaphylaxis. Dinitrophenyl-polylysines evoked urticarial responses non-specifically, but after succinylation were about as effective as dinitrophenyl-proteins in eliciting specific cutaneous reactions. An important factor influencing the effectiveness of bis-DNP-lysine in evoking specific wheal-and-erythema responses is antibody affinity for the dinitrophenyl-lysyl determinant.

Submitted on November 21, 1961


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