The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 555-562, Copyright, 1962, by The Rockefeller Institute

ARTICLE

INHIBITION OF CYTOCHROME OXIDASE BY AMINOACETONITRILE

J. J. Clemmons M.D.1 and E. B. Jackson Jr. 1

1 From the Institute of Pathology, Western Reserve University, Cleveland

Aminoacetonitrile (AAN) decomposes with the formation of a substance that is a potent inhibitor of cytochrome oxidase. The inhibitor is probably cyanide. Connective tissue contains cytochrome oxidase that varies in amount with the maturity of the tissue and is also inhibited by the product of AAN decomposition.

Submitted on November 2, 1961


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