The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 513-525, Copyright, 1962, by The Rockefeller Institute

ARTICLE

AN IMMUNOLOGIC STUDY OF TWO METABOLICALLY ACTIVE PEPTIDES FROM THE ANTERIOR PITUITARY GLAND

Henry Friesen M.D.1, Minoru Irie M.D.1, and Richard J. Barrett M.D.1

1 From the Ziskind Research Laboratories, Pratt Clinic, New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston

Peptides I and II, two metabolically active peptides from porcine pituitary glands, stimulated antibody production in rabbits. The antiserum obtained had antibodies which interacted with peptides I and II from porcine pituitaries, peptides I and II from human pituitaries, and fraction H prepared by Rudman from hog pituitaries. None of the other pituitary preparations tested showed any interaction with peptides I and II.

All three preparations stimulated the release of free fatty acids from rabbit adipose tissue in vitro. Antiserum inhibited this biological action to a different extent in each of the three preparations. Following an intravenous injection of peptides I and II there was a rapid rise in the plasma concentration of free fatty acids in rabbits. Injection of antiserum together with peptides I and II failed to block the rapid increase in free fatty acids. However, an injection of at least ten times the minimal amount of peptides I and II which raised the plasma free fatty acid concentration produced no increase in a rabbit with a high antibody titer to these peptides.

 Submitted on October 18, 1961


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