The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 115, 503-512, Copyright, 1962, by The Rockefeller Institute

ARTICLE

THE ROLE OF INTERFERON IN VACCINIA VIRUS INFECTION OF MOUSE EMBRYO TISSUE CULTURE

Lowell A. Glasgow M.D.1 and Karl Habel M.D.1

1 From the Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, United States Department of Health, Education, and Welfare

The production of an interferon-like substance by vaccinia virus is described. The physical properties of vaccinia interferon are shown to be similar to those of previously reported interferons.

Data defining the role of vaccinia interferon in cell resistance and in establishment and maintenance of a carrier culture are presented.

Elimination of virus from an infected culture is demonstrated and the role of interferon in the recovery process is considered.

 Submitted on October 29, 1961


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