THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

doi:10.1084/jem.115.3.453

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The Journal of Experimental Medicine, Vol 115, 453-466, Copyright, 1962, by The Rockefeller Institute

ARTICLE

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

Stephen Boyden Ph.D.¹

¹ From the Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra

An in vitro technique is described for assessing the chemotacticactivity of soluble substances on motile cells.

Antibody-antigenmixtures when incubated (37°C) in medium containing fresh(i.e. non-inactivated) normal rabbit serum exert a strong chemotacticeffect on rabbit polymorphonuclear leucocytes.

Results are describedwhich indicate that, when antibody-antigen complexes are incubated(37°C) in fresh serum, a heat-stable (56°C) substance(or substances) is produced which acts directly as a chemotacticstimulus on the polymorphs. This heat-stable chemotactic substanceis not produced when antibody-antigen complexes are incubatedin serum which has been heated at 56°C for 30 minutes.

Submitted on August 21, 1961

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