The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 114, 509-520, Copyright, 1961, by The Rockefeller Institute

ARTICLE

THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS : I. PASSIVE TRANSFER OF ISOIMMUNE SERUM TO CONDITIONED HOSTS



Roberto R. Kretschmer 1 and Ruy Peréz-Tamayo M.D.1

1 From the Unidad de Patología, the Faculty of Medicine, National University of Mexico, General Hospital, Mexico

Gross and microscopic observations of skin homograft rejection carried out in cortisone-conditioned and non-conditioned rabbits seem to indicate that humoral antibodies play an important role in the phenomenon. Thus, local administration of isoimmune serum to animals bearing skin homografts resulted in a significantly earlier rejection of that particular test graft without modifying the course of a neighboring control-skin graft. This result appears to support the idea that homograft rejection is not only due to cellular antibodies but to a combination of both humoral and cellular immune responses, which should not be regarded as completely unrelated.

Submitted on May 31, 1961


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