The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 114, 231-236, Copyright, 1961, by The Rockefeller Institute

ARTICLE

EFFECTS OF CHRONIC EXCESS SALT FEEDING : INDUCTION OF SELF-SUSTAINING HYPERTENSION IN RATS



Lewis K. Dahl M.D.1

1 From the Medical Research Center, Brookhaven National Laboratory, Upton, New York

Hypertension was induced in female rats by chronic feeding of sodium-containing salts in excess. The hypertension so induced appeared to be self-sustaining since about two-thirds of the animals failed to show a significant fall in blood pressure after withdrawal of these salts from the diet.

Under the conditions of these experiments a lack of response to restriction of dietary sodium does not exclude an etiologic relationship between salt intake and development of hypertension.

 Submitted on April 9, 1961


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