The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 114, 173-183, Copyright, 1961, by The Rockefeller Institute

ARTICLE

THE EFFECT OF AMINOMETHYLPTEROYLGLUTAMIC ACID ON THE DEVELOPMENT OF SKIN HYPERSENSITIVITY AND ON ANTIBODY FORMATION IN GUINEA PIGS

Robert M. Friedman M.D.1, Charles E. Buckler 1, and Samuel Baron M.D.1

1 From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda

1. In guinea pigs, aminomethylpteroylglutamic acid (methotrexate) is capable of blocking the development of delayed skin hypersensitivity, the primary antibody response, and the specific febrile response to ovalbumin and diphtheria toxoid. The primary antibody response is more easily inhibited than is the development of delayed skin hypersensitivity.

2. The effect of methotrexate on immunologic responses depended upon the dose of methotrexate employed and the strength of the antigenic stimulus.

 Submitted on March 26, 1961


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