The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 834K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holliday, M. A.
Right arrow Articles by Oliver, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holliday, M. A.
Right arrow Articles by Oliver, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 113, 971-980, Copyright, 1961, by The Rockefeller Institute

ARTICLE

THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : III. THE EFFECT OF ACUTE CHLORIDE DEPLETION AND ALKALOSIS ON THE RENAL CORTEX



Malcolm A. Holliday M.D.1, Nancy H. Bright M.D.1, Dale Schulz M.D.1, and Jean Oliver M.D.1

1 From the Heinz Memorial Laboratory, Children's Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and the Renal Research Unit, CIBA Pharmaceutical Products, Inc., Summit, New Jersey

Acute chloride depletion in rats is associated with the occurrence of an extensive cell damage in the mid-portion of the proximal convolutions which is followed by an excessive hyperplastic reaction of the renal epithelium; no other significant lesions were found by microdissection in either the tubules of the nephrons or the collecting system.

Potassium deficiency is not essential to the development of this lesion but does increase the severity of the reaction.

As in the case of potassium deficiency, chloride depletion predisposes to or exaggerates the structural alterations that accompany excess phosphate intake.

The relations of the different structural changes in renal architecture that occur in various states of electrolyte imbalance are discussed as well as the relation of the lesions seen experimentally in the rat and monkey and clinically in man.

 Submitted on February 6, 1961


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS