PERSISTENCE OF TYPE-SPECIFIC ANTIBODIES IN MAN FOLLOWING INFECTION WITH GROUP A STREPTOCOCCI

doi:10.1084/jem.110.2.271

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The Journal of Experimental Medicine, Vol 110, 271-292, Copyright, 1959, by The Rockefeller Institute

ARTICLE

PERSISTENCE OF TYPE-SPECIFIC ANTIBODIES IN MAN FOLLOWING INFECTION WITH GROUP A STREPTOCOCCI

Rebecca C. Lancefield Ph.D.¹

¹ From The Rockefeller Institute

Whole blood or sera were collected from individuals who hadhad infections with Group A streptococci of known serologicaltype as long ago as 10 to 32 years. Most of these patients hadnot been treated with chemotherapeutic drugs. By means of bactericidaltests with all these sera, and mouse protection tests with some,type-specific antibodies could be demonstrated in at least halfof them after a lapse of many years, the longest interval being32 years.

Two biological methods for estimating the amount ofM antigen produced by Group A streptococci are described. Byselecting strains for use by these methods, optimal proportionsof M antigen and antibody could be employed in the tests andsmall amounts of antibody were, therefore, demonstrable.

Theassay methods for M antigen are also of value for other experimentalpurposes.

Submitted on April 16, 1959

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