The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 110, 245-258, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE STREPTOKINASE-PLASMINOGEN SYSTEM : I. ITS EFFECT ON THE PATHOGENICITY OF STREPTOCOCCI AND OTHER ORGANISMS FOR MICE



Robert I. Krasner Ph.D.1 and Genevieve Young Ph.D.1

1 From the Department of Serology and Immunology, Medical General Laboratory (406), United States Army Medical Center, Japan, and the Department of Biology, Boston University, Boston

Human plasminogen, plasma, or serum increased the pathogenicity of six streptokinase-positive streptococcal strains for mice. Combinations of commercial streptokinase and plasminogen or streptokinase and plasma did not usually increase mouse mortality to a greater degree than did plasminogen or plasma alone, suggesting that the maximal effective amount of streptokinase was produced by the organisms.

The pathogenicity of Salmonella paratyphi (fibrinolysin variable) and a Group D streptococcus (streptokinase-negative) was not increased by plasminogen, plasma, or streptokinase, whereas a combination of streptokinase and plasminogen, or streptokinase and plasma did significantly increase mouse mortality resulting from these organisms.

Combinations of certain concentrations of streptokinase and plasminogen increased the pathogenicity of a fibrinolysin-negative staphylococcal strain for mice to a greater extent than did either substance alone.

The observed results provide evidence that streptokinase, by an interaction with plasminogen, contributes to the pathogenicity of streptokinase-positive streptococci.

 Submitted on March 19, 1959


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