The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 110, 161-168, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE RENAL LESIONS OF ELECTROLYTE IMBALANCE : II. THE COMBINED EFFECT ON RENAL ARCHITECTURE OF PHOSPHATE LOADING AND POTASSIUM DEPLETION



M. A. Holliday M.D.1, R. W. Winters M.D.1, L. G. Welt M.D.1, Muriel MacDowell 1, and Jean Oliver M.D.1

1 From the Department of Pediatrics, Indiana University Medical Center, Department of Pediatrics and Department of Medicine, University of North Carolina, and the Renal Research Unit, Research Department, CIBA Pharmaceutical Products Inc., Summit, New Jersey

Potassium depletion in rats augments the specific renal lesions of phosphate loading.

Since it has been shown that phosphate loading increases the specific cardiac lesions of potassium deficiency (12), it is concluded that the similar types of electrolyte imbalance (potassium depletion-phosphate load) act conversely in the two organs.

 Submitted on February 23, 1959


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