The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 109, 601-614, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE METABOLISM OF SILICON IN THE RAT AND ITS RELATION TO THE FORMATION OF ARTIFICIAL SILICEOUS CALCULI

Richard F. Keeler Ph.D.1 and Stuart A. Lovelace D.V.M.1

1 From the Montana Veterinary Research Laboratory (Montana Experiment Station and Livestock Sanitary Board Cooperating), Montana State College, Agricultural Experiment Station, Bozeman

The urinary excretion of silicon in the rat was found to be enhanced beyond normal levels by the administration of various chemical forms of silicon. The excretion was enhanced to a much greater degree by the administration of ethyl silicate than by magnesium trisilicate, sodium metasilicate, or water glass. The tolerance level of rats to sustained daily doses of ethyl silicate fed via stomach tube was approximately 15 to 30 mg. of silicon per rat per day. Urinary silicon excretion was found to be a straight line function of the concentration of ethyl silicate administered, via stomach tube, with approximately 18 per cent of the administered silicon appearing in the urine at all levels tested. Using sustained dietary additions of ethyl silicate as a means of enhancing urine silicon levels, artificial siliceous urinary calculi were consistently produced on zinc pellets implanted in the bladders of rats.

Submitted on January 16, 1959


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