The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 109, 505-510, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS : I. ULTRASTRUCTURAL STUDIES



Burton Goldberg M.D.1 and Howard Green M.D.1

1 From the Department of Pathology, New York University—Bellevue Medical Center, New York

Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.

Submitted on December 28, 1958


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