The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 108, 639-649, Copyright, 1958, by The Rockefeller Institute

ARTICLE

STUDIES OF THE PLASMIN SYSTEM : III. PHYSICAL PROPERTIES OF THE TWO PLASMIN INHIBITORS IN PLASMA



Philip S. Norman M.D.1 and Betsy M. Hill 1

1 From the Immunology Division, Department of Medicine, The Johns Hopkins University, Baltimore

There are two inhibitors of plasmin in the plasma proteins of the human. alpha1-antiplasmin is heat-labile and migrates as an alpha1-globulin on electrophoresis. It combines non-dissociably with plasmin at a rate that depends on temperature.

alpha2-antiplasmin is relatively more heat-stable and migrates as an alpha2-globulin on electrophoresis. It combines dissociably with plasmin independently of temperature.

 Submitted on July 2, 1958


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