The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 108, 325-328, Copyright, 1958, by The Rockefeller Institute

ARTICLE

GLYCYRRHIZIN-INDUCED INHIBITION OF THE PITUITARY-ADRENAL STRESS RESPONSE

Shirley D. Kraus Ph.D.1

1 From the Department of Pharmacology, Howard University College of Medicine, Washington, D. C.

Glycyrrhizin decreased the resistance of intact male mice to prolonged exposure to cold (8 hours at 5°C.) and it decreased the ability of intact male rats to mobilize glucose when subjected to 48 hours of fasting. It is suggested that glycyrrhizin, like desoxycorticosterone, depresses the output of ACTH.

Submitted on May 15, 1958


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