The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 108, 299-309, Copyright, 1958, by The Rockefeller Institute

ARTICLE

NEUTRALIZING ANTIBODIES TO STREPTOCOCCAL DIPHOSPHOPYRIDINE NUCLEOTIDASE IN THE SERUM OF EXPERIMENTAL ANIMALS AND HUMAN BEINGS

Aaron Kellner M.D.1, Elizabeth B. Freeman 1, and Arthur S. Carlson M.D.1

1 From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

Specific neutralizing antibodies directed against streptococcal DPNase were induced experimentally in rabbits and guinea pigs by the injection of partially purified preparations of the enzyme. Similar antibodies capable of inhibiting the biological activity of the enzyme were found to occur naturally in the serum of a very high percentage of human beings, and the titer of these antibodies often rose sharply following streptococcal infections. The antibody response to streptococcal DPNase in general paralleled that to streptolysin O, though in some instances antibodies to one increased when those to the other did not.

Submitted on May 9, 1958


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