The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 108, 277-282, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON EXPERIMENTAL SHIGELLOSIS : II. THE EFFECT OF FASTING AND FATIGUE ON SHIGELLA FLEXNERI 3 INFECTIONS IN MICE



C. David McGuire Ph.D.1 and Thomas M. Floyd 1

1 From the Naval Medical Research Institute, National Naval Medical Center, Bethesda

Host resistance to Shigella infections can be decreased by non-specific physical stress. Fasting lowers the number of Shigella required for a parenteral LD50 dose. While the LD50 by the oral route is larger in fasted than in nonfasted animals, the fasted host's susceptibility to oral infection is increased as evidenced by the increased fecal Shigella carrier state, duration of intestinal infection, and increased incidence of Shigella bacteriemia.

Fatigue also increases the animal's susceptibility to shigellosis, but to a lesser extent than does fasting.

 Submitted on April 16, 1958


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