The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 108, 121-130, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE FORMATION OF MYELOMA PROTEIN BY A MOUSE PLASMA CELL TUMOR

Daniel Nathans M.D.1, John L. Fahey M.D.1, and Michael Potter M.D.1

1 From the Metabolism Service and the Leukemia Studies Section, National Cancer Institute, National Institutes of Health, Bethesda

The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the plasma of these animals were compared following intravenous injection of L-lysine-C14. The results indicate that myeloma protein is synthesized in the plasma cell tumor.

Submitted on February 27, 1958


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