The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 107, 821-828, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D

Leonard F. Bélanger M.D.1 and B. B. Migicovsky Ph.D.1

1 From the Department of Histology and Embryology, School of Medicine, University of Ottawa, and Chemistry Division (Contribution No. 385), Science Service, Department of Agriculture, Ottawa

One day old chicks were fed a vitamin D-deficient diet for 3 weeks. Some were then given an oral dose of vitamin D and sacrificed at various times thereafter. The tibiae were x-rayed; demineralized sections were stained for neutral polysaccharides and sulfated mucopolysaccharides; other specimens were ashed; and others still were autoradiographed to determine their uptake of Ca45 in vitro.

Mineralization reappeared in the treated animals after 2 days, along with new P.A.S.-positive spicules.

Earlier, the immature cartilage rapidly matured morphologically. At the same time, the rachitic matrix, highly concentrated in cation binder, presumably chondroitin sulfate, lost this material progressively.

 Submitted on December 22, 1957


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