The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 107, 633-641, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

ADSORPTION AND MATURATION OF POLIOVIRUS IN SINGLY AND MULTIPLY INFECTED HELA CELLS

James E. Darnell Jr. M.D.1

1 From the Section on Experimental Therapeutics, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Studies with polio-infected HeLa cells using cell disruption techniques during the early stages of infection have shown that:

The inoculum of poliovirus adsorbed on HeLa cells is largely inactivated. Infective virus accumulates in a monolayer sheet of cells in advance of release into the medium.

The eclipse period is shorter in multiply infected cells than in those infected with a single particle.

 Submitted on January 12, 1958


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