The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 107, 581-598, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

BLOOD PRESSURE, CHOLESTEROL CONTENT OF SERUM AND TISSUES, AND ATHEROGENESIS IN THE RAT : THE EFFECT OF VARIATIONS IN BLOOD PRESSURE ON THE CHOLESTEROL CONTENT OF SERUM AND TISSUES AND ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN RATS ON A HIGH CHOLESTEROL DIET



Q. B. Deming M.D.1, E. H. Mosbach Ph.D.1, M. Bevans M.D.1, M. M. Daly Ph.D.1, L. L. Abell Ph.D.1, E. Martin 1, L. M. Brun 1, E. Halpern 1, and R. Kaplan 1

1 From the Columbia University Research Service, Goldwater Memorial Hospital and the Departments of Medicine and Biochemistry, College of Physicians and Surgeons, Columbia University, New York

Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endogenous cholesterol synthesis. Rats with high serum lipide concentrations developed intimal lesions similar to those of human atherosclerosis.

The induction of hypertension by desoxycorticosterone and salt accelerated the development of hypercholesterolemia, hyperlipemia, increase in tissue cholesterol content, and atherosclerotic changes in the intima. Hypertension induced by renal artery constriction also intensified the hypercholesterolemia and hyperlipemia. On the other hand, rats receiving desoxycorticosterone acetate without salt or salt without desoxycorticosterone acetate did not show any intensification of hypercholesterolemia or hyperlipemia.

The extent of the atherosclerotic lesions was correlated with the concentration of cholesterol in the serum. There was also a positive correlation between blood pressure and the degree of hypercholesterolemia. It remained uncertain whether the increase in atherosclerosis in the hypertensive animals was dependent on the increased lipide content of serum and tissues or on a local effect of the elevated blood pressure.

 Submitted on October 16, 1957


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