The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 100, 289-300, Copyright, 1954, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE TRANSFER OF LYMPH NODE CELLS : IV. EFFECTS OF X-IRRADIATION OF RECIPIENT RABBITS ON THE APPEARANCE OF ANTIBODY AFTER CELL TRANSFER



T. N. Harris M.D.1, Susanna Harris Ph.D.1, Henry D. Beale M.D.1, and J. J. Smith M.D.1

1 From The Children's Hospital of Philadelphia, the Departments of Pediatrics and Medicine, University of Pennsylvania, the Division of Immunology, Department of Public Health and Preventive Medicine, Graduate School of Arts and Sciences, University of Pennsylvania, and the Department of Radiology, Graduate Hospital, University of Pennsylvania, Philadelphia

Cells of the popliteal lymph node were teased 3 days after the injection of Shigella paradysenteriae into the hind foot pads of rabbits. These cells were transferred to normal and x-irradiated recipients. It was noted that the serum titers of dysentery agglutinins in irradiated recipients were higher than in normal recipients. This was represented both in a higher peak: titer and a tendency to remain higher for a longer period than in normal animals.

Recipients were x-irradiated within 1 hour after receiving cells of the lymph node prepared as indicated above. The serum titers of these recipients were markedly reduced in comparison with those of non-irradiated control animals. If the irradiation of the recipients followed the transfer of cells by a day, however, this difference was much smaller and in the case of a 2 day interval after the transfer of the lymph node cells the irradiation appeared to have no effect on the resulting serum titer.

 Submitted on June 14, 1954


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